Evaluation of Five Mammalian Models for Human Disease Research Using Genomic and Bioinformatic Approaches

The suitability of an animal model for use in studying human diseases relies heavily on the similarities between two species at genetic, epigenetic, and metabolic levels. However, there is a lack consistent data from different models each level to evaluate this suitability. With availability genome sequences many mammalian species, it now possible compare based genomic similarities. Herein, we coding (CDSs) five models, including rhesus macaque, marmoset, pig, mouse, rat with sequences. We identified 10,316 conserved CDSs across organisms sequence similarity. Mapping human-disease-associated single-nucleotide polymorphisms (SNPs) these has species-specific associations various diseases. While disease such as colon cancer were prevalent multiple macaque showed most model-specific associations. Based percentage disease-associated SNP-containing genes, marmoset are well suited study ailments, behavioral cardiovascular This demonstrates similarity evaluation against that could help investigators select suitable their target disease.